Literature summary extracted from

Xu, X.; Ma, J.; Li, C.; Zhao, W.; Xu, Y.
Regulation of chondrosarcoma invasion by MMP26 (2015), Tumour Biol., 36, 365-369.

Application

EC Number	Application	Comment	Organism
3.4.24.B7	medicine	matrix metalloproteinase MMP26 level is significantly higher in the resected chondrosarcoma than in the adjacent healthy chondral tissue from patients. Overexpression of MMP26 in SW-1353 cells increases cell invasiveness, while inhibition of MMP26 decreases cell invasiveness. Inhibition of Wnt signaling significantly decreases the effect of MMP26 on cancer cell invasion. A strong correlation is detected between MMP26 levels and the ratio of phosphorylated/total beta-catenin in chondrosarcoma from the patients	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B7	Homo sapiens	Q9NRE1	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.B7	SW-1353 cell	chondrosarcoma cell line	Homo sapiens	-

General Information

EC Number	General Information	Comment	Organism
3.4.24.B7	physiological function	overexpression of MMP26 in SW-1353 chondrosarcoma cells increases cell invasiveness, while inhibition of MMP26 decreases cell invasiveness. Inhibition of Wnt signaling significantly decreases the effect of MMP26 on cancer cell invasion	Homo sapiens

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Release 2023.1 (January 2023)